The Kansas City Chiefs and Los Angeles Chargers will meet in Brazil on Friday in the 2025 NFL Sao Paulo game. Kansas City has won seven straight in the head-to-head series, sweeping the season series three years in a row. The reigning AFC champions are heavy -166 favorites on the money line to win their eighth straight against the Bolts, according to the latest Chiefs vs. Chargers odds at DraftKings Sportsbook.

Kickoff from Neo Quimica Arena in Sao Paulo is set for 8 p.m. ET. Kansas City is a 3-point favorite in the latest Chargers vs. Chiefs odds at DraftKings, while the over/under for total points scored is 47.5. Before locking in your Chiefs vs. Chargers picks and parlays at DraftKings Sportsbook, be sure to check out the best NFL bets for today from SportsLine's proven computer model.

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