The first international game of the 2025 NFL season is on tap with a high-stakes AFC West showdown featuring the Kansas City Chiefs and the Los Angeles Chargers in the NFL Sao Paulo Game on Friday at 8 p.m. ET at Corinthians Arena. Kansas City is a 3-point favorite, while the over/under is 47.5. There will be millions of dollars on the line in NFL DFS tournaments, cash games and 50-50's on FanDuel and DraftKings, so finding DFS sleepers and building lineup variance will be critical for this single-game slate. Chiefs quarterback Patrick Mahomes has a lengthy track record of success against the Chargers, but should you include him in your NFL DFS lineups for the NFL Sao Paulo Game?

Other big names in the Chiefs vs. Chargers DFS player pool include Travis Kelce, Justin Herbert, Isiah Pacheco

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