Five 49ers to watch in Week 1 showdown vs. Seahawks as 2025 NFL season kicks off “Lenoir will not face the interesting challenges of past 49ers-Seahawks games before DK Metcalf is now a member of the Pittsburgh Steelers. But this is not an easy assignment for him and fellow starter Renardo Green.

Seahawks quarterback Sam Darnold will try to get the ball into the hands of former Los Angeles Rams standout Cooper Kupp and Jaxon Smith-Njigba, who had 100 receptions for 1,130 yards last season.“

49ers vs. Seahawks: The Standard’s 5 fast predictions (paywall) “Kawakami: 49ers 20, Seahawks 17. Brock Purdy probably can’t win this himself — the 49ers’ young defense will have to hold up against the Seattle running game and the special teams can’t mess up. This will be tense until the end. But Purd

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