Thunder Dan's favorite RB matchups to exploit for Week 1 of 2025 - DFS running backs to target on DraftKings and FanDuel. These RB matchups are GPP and cash game opportunities.

Every week of the NFL season, we have to weigh the opportunities that we project for each running back against the quality of the opposing run defense. There are only a handful of backs that are guaranteed so many touches that we can look past their matchup and plug them into lineups without hesitation (the Saquon Barkley s and Bijan Robinson types).

But most NFL running backs are much more matchup-dependent, and in the DFS/betting space, we love evaluating weekly matchups to find the optimal plays or wagers.

My goal in this article will be to highlight the absolute best matchups for running backs on Sunday,

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