The Arizona Cardinals open their 2025 season as road favorites against the New Orleans Saints on Sunday at Caesars Superdome. With Kyler Murray healthy and a fresh set of offensive weapons around him, Arizona is looking to build early momentum in what’s expected to be a competitive NFC playoff picture. The Saints, meanwhile, turn to rookie quarterback Spencer Rattler in his first NFL start, hoping the home crowd can give New Orleans a spark in the opener.

Oddsmakers have Arizona as 6.5-point favorites, priced at -275 on the moneyline, while New Orleans sits at +240. The total is set at 43.5 points, reflecting expectations for a moderately low-scoring game. According to Dimers.com’s predictive model , the Cardinals have a 73% chance of winning after 10,000 simulations, with a projected 2

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