The Tennessee Titans and the Denver Broncos meet on Sunday in Week 1 of the 2025 season at Empower Field at Mile High. Kickoff is set for 4:05 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the Titans vs. Broncos odds and make our expert NFL picks and predictions for the best bets.

The Titans endured a brutal 2024 season, finishing with a franchise-worst 3-14 record and missing the playoffs for the third straight year. A 1–6 start, instability at quarterback, and a lack of offensive production left the team searching for answers, with coach Brian Callahan calling the season “embarrassing” and vowing to reset the team’s direction.

That reset began with the No. 1 overall pick, as the Titans drafted quarterback Cam Ward to be their new franchise leader.

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