The Arizona Cardinals visit the New Orleans Saints Sunday to open the 2025 season. Kickoff from Caesars Superdome is at 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the Cardinals vs. Saints odds and make our expert NFL picks and predictions for the best bets.

The Cardinals are coming off an 8-9 season in which 8 of their 9 losses were to teams with at least 10 wins. The offensive starting lineup returns almost unchanged, but they added help defensively. LB Josh Sweat , DL Dalvin Tomlinson and DL Calais Campbell signed in free agency and DL Darius Robinson , a first-round pick in 2024, is healthy to start the season.

The Saints begin the Kellen Moore era. Moore was named head coach this offseason, replacing Dennis Allen, and he brought with him

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