The San Francisco 49ers and the Seattle Seahawks open their seasons Sunday. Kickoff from Lumen Field is scheduled for 4:05 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Seahawks odds and make our expert NFL picks and predictions for the best bets.

The 49ers reshaped their roster this offseason, trading WR Deebo Samuel to the Washington Commanders and reuniting with former New York Jets coach Robert Saleh, who returns as defensive coordinator. Free agency departures included LB Dre Greenlaw , S Talanoa Hufanga , CB Charvarius Ward and G Aaron Banks , while San Francisco added RB Brian Robinson Jr. from the Commanders. The 49ers stumbled to a 6-11 finish in 2024, last in the NFC West, as injuries to stars such as RB Christian McCaf

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