Aug 9, 2025; Glendale, Arizona, USA; Arizona Cardinals tight end Trey McBride (85) against the Kansas City Chiefs during a preseason NFL game at State Farm Stadium.

The 2025 NFL season has officially begun and the first Sunday of the season is here.

All 32 teams open the campaign with hopes of competing in Super Bowl 60 in February.

The top contenders include the Baltimore Ravens and Buffalo Bills at the head of the field in the AFC. Meanwhile in the NFC the defending champion Philadelphia Eagles are being pursued by the Detroit Lions, Green Bay Packers and San Francisco 49ers along with several other notables.

With the bulk of NFL Week 1 action taking place on Sunday, the USA TODAY Sports staff of NFL experts provides the best NFL bets of Week 1 in one place below.

Our experts have provided the best prediction for this weekend's slate of games, selecting from any betting markets available and supplying an in-depth analysis on spreads, totals, player props and anytime touchdowns. Here are our best NFL bets for Sunday games with odds from BetMGM. Best of luck if you tail.

Best bets NFL Week 1

All odds listed are provided by BetMGM Sportsbook. Access USA TODAY Sports Scores and Sports Betting Odds hub for a complete list.

Patriots WR Stefon Diggs OVER 64.5 receiving yards vs. Raiders (-110)

Ayrton Ostly, NFL writer: Things are looking much better for the Patriots offense than they did 12 months ago. Quarterback Drake Maye has a year of experience under his belt and now gets a proven offensive coordinator in Josh McDaniels in addition to improved talent up front.

Diggs suffered a serious knee injury last season but starts 2025 as the Patriots' top wide receiver. He's a proven player who New England can rely on more than any other wideout they had last year.

He's facing arguably the worst cornerback room in the league in Week 1. Las Vegas' defensive coordinator Patrick Graham is a very good playcaller but there's only so much he can do in Week 1 with the talent he's been given. Look for Diggs to get the target volume to exceed this yardage total.

Cleveland Browns vs. Cincinnati Bengals OVER 47.5 (-115)

Jacob Camenker, NFL writer: Nothing says, "The NFL is back!" quite like predicting a shootout in a game where 40-year-old Joe Flacco is one of the starting quarterbacks.

Flacco may not inspire confidence long-term for Browns fans, but the veteran's gunslinger mentality should afford him plenty of scoring chances against the Bengals defense. Cincinnati allowed 25.5 points per game last season (seventh-most in the NFL last season) and is breaking in a new defensive coordinator, Al Golden, who may need time to mold the unit in his image.

Meanwhile, trusting Joe Burrow and the Bengals offense after Zac Taylor decided to play his offensive starters in the preseason to get off to a faster start seems like a no-brainer.

Cardinals TE Trey McBride OVER 61.5 receiving yards vs. Saints (-115)

Jack McKessy, NFL writer: McBride established himself as Cardinals quarterback Kyler Murray's favorite target in the passing game last season, racking up 111 catches for 1,146 yards on 147 targets, all of which led the team. Last year, McBride put up more than 61 yards in 10 out of the 16 games he played in.

Meanwhile, the Saints may have one of the worst defensive secondaries in the NFL after trading cornerback Marshon Lattimore, letting fellow cornerback Paulson Adebo walk in free agency and seeing safety Tyrann Mathieu retire.

Colts TE Tyler Warren OVER 3.5 receptions vs. Dolphins (-145)

Nick Brinkerhoff, NFL writer: They don't make tight ends like they used to. It was previously a position that struggled to adjust to the NFL game, but players like Brock Bowers did a good job of helping that narrative vanish. Enter Warren, who was taken in the first round by the Colts and is the clear TE1.

The team invested a lot in the Penn State product and has put an emphasis on ensuring they get their money's worth. Daniel Jones isn't an easy quarterback to trust, but Warren's ability to be a security blanket for him is certainly attractive. Miami's defense is loaded with questions and an overall lack of depth. Indianapolis' receivers don't inspire a lot of confidence, leaving the door open for Warren to take advantage. Given his yards after catch (YAC) ability, there should be plenty of chances for the rookie to create after the catch – making him a target monster in his debut.

Falcons WR Drake London OVER 73.5 receiving yards (-115)

Tom Viera, NFL writer/editor: The Falcons host the Buccaneers in Week 1 and this matchup has the second-highest total of the week. Last season, they combined for 66 points in Week 5 and 57 points in Week 8, and there's little reason to expect things to be different in 2025. Tampa Bay allowed the third-most passing yards per game last season, and Todd Bowles' predominantly Cover-3 defense leads the secondary susceptible to wide receiver production.

London played three games with Michael Penix Jr. in 2024, and his massive target rate across those games gives reason to believe London could be a contender for the receiving triple crown in 2025. Darnell Mooney missed time this preseason dealing with a shoulder injury, and could be limited if active. London has exceeded 100 yards in all three career matchups at home against Tampa Bay. He's in a position to do so again to kick off 2025.

This article originally appeared on USA TODAY: What are NFL best bets for Week 1? We asked our experts for top predictions, player props

Reporting by Tom Viera, USA TODAY / USA TODAY

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