Isaac Guerendo, Rashod Bateman, Deebo Samuel Sr. fantasy football start 'em, sit 'em picks for Week 1 (2025). Should you start or sit Isaac Guerendo, Rashod Bateman, Deebo Samuel Sr. in Week 1?

Week 1 of the fantasy season is finally here. At this point, your league has drafted, and you are parsing through all the relevant information to figure out who should be in your lineup for Week 1.

In the opening week, several veteran options have difficult matchups which can make it tough for managers to put them in their starting lineup in the opening week.

Can fantasy managers start Isaac Guerendo , Rashod Bateman , and Deebo Samuel Sr. in Week 1? Read below to find out. Be sure to check all of our fantasy football rankings for 2025:

2025 fantasy football rankings

Running back (RB)

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