The New England Patriots and Las Vegas Raiders kick off the 2025 NFL season with an AFC matchup. Las Vegas finished last season with a 4-13 record. The Raiders decided to fire Antonio Pierce and brought in Pete Carroll to be the new head coach. It's a similar story for New England, which notched a 4-13 campaign as well and axed Jerod Mayo. Mike Vrabel has returned to the Patriots, but as their head coach this time.

Kickoff from Gillette Stadium is set for 1 p.m. ET on Sunday, Sept. 7. New England is favored by 2.5 points in the latest Raiders vs. Patriots odds at bet365 Sportsbook, while the over/under for total points scored is 43.5. Before making any Patriots vs. Raiders picks or same-game parlays, be sure to see the Week 1 NFL predictions from SportsLine's proven model and check out th

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