Baltimore Ravens running back Derrick Henry (22) runs the ball for a touchdown during the second quarter against the Buffalo Bills at Highmark Stadium in Orchard Park, New York on Sept. 7, 2025.

Baltimore Ravens running back Derrick Henry was the Buffalo Bills' Kryptonite during the 2024 NFL season. That trend carried over into the early stages of their 2025 matchup.

Henry ran roughshod over the Bills in the first half of the Ravens' Week 1 matchup with their AFC rival. He ripped off separate gains of 30 and 49 yards in the first half alone and could challenge his career high in rushing yards if the second half goes well.

While Henry continued to run well in the second half, he made a key gaffe late in the contest. He lost a fumble on Baltimore's penultimate drive, which set the Bills up to score and played a major role in Buffalo's 15-point fourth-quarter comeback.

Here's what to know about Henry's performance in the 41-40 loss against the Bills and how it compares to some of his best outings.

Derrick Henry stats today

Henry racked up 123 rushing yards in the first half of the Ravens' Week 1 game against the Bills. Buffalo did a better job of slowing him after halftime, but he still posted solid stats during the contest.

Below is a look at his stats from the game:

  • Carries: 18
  • Rushing yards: 169
  • Rushing TDs: 2
  • Yards per carry: 9.4

As mentioned, Henry had a critical fumble on Baltimore's penultimate possession. He has also logged one reception for 13 yards during the game.

Derrick Henry stiff arm

Henry's biggest highlight against the Bills came on his 30-yard touchdown run. He was able to clear Buffalo safety Cole Bishop out of his path with a crushing stiff arm.

Henry (6-2, 252 pounds) has long been notorious for his devastating stiff arm. This one will simply be the latest to grace his career highlight reel.

Derrick Henry's most rushing yards in a game

Henry's career-high single-game rushing total is 250 yards. He achieved that feat in Week 17 of the 2020 NFL season against the Houston Texans.

Henry has totaled at least 200 rushing yards in six career games. All came during his eight seasons with the Tennessee Titans.

Most rushing yards in an NFL game

Adrian Peterson has the most rushing yards in a single game in NFL history. He ran for 296 yards against the then-San Diego Chargers in Week 9 of his rookie 2007 season.

Henry's career-high 250 rushing yards rank is tied with O.J. Simpson and Spec Sanders for the 14th-most in NFL history.

NFL career rushing leaders

Henry entered Sunday's game with 11,423 career rushing yards to his name, good for the 19th-most in NFL history. He passed Steven Jackson (11,438 yards) early in the game and should soon move ahead of Fred Taylor (11,695) to get to 17th on the list.

Henry may have a chance to move into the top 10 all-time by the end of the 2025 NFL season. Here's a look at who graces the top of the NFL's rushing leaderboard:

  1. Emmitt Smith: 18,355
  2. Walter Payton: 16,726
  3. Frank Gore: 16,000
  4. Barry Sanders: 15,269
  5. Adrian Peterson: 14,918
  6. Curtis Martin: 14,101
  7. LaDanian Tomlinson: 13,684
  8. Jerome Bettis: 13,662
  9. Eric Dickerson: 13,259
  10. Tony Dorsett: 12,739

This article originally appeared on USA TODAY: Derrick Henry stats today: Ravens RB dominates vs. Bills but has key fumble

Reporting by Jacob Camenker, USA TODAY / USA TODAY

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