After a strong defensive win at home in Week 1, the Denver Broncos will be on the road next week to take on the Indianapolis Colts who are also coming off a huge offensive and defensive dominant win on Sunday. Both teams are 1-0 heading into Week 2, but it is Denver who might have some questions to answer about their offense in this next one.

According to FanDuel, the Broncos are 2.5-point road favorites against the Colts in Week 2. The over/under stands at 43.5 for this matchup.

Broncos vs. Colts betting odds

Denver Broncos at Indianapolis Colts Sunday, September 14, 2025 at 2:05 P.M. Mile High time Lucas Oil Stadium in Indianapolis, Indiana ATS Betting Lines: Denver -2.5 Moneyline Odds: Denver -144 / Indianapolis +122 Over/Under: 43.5

Sunday was a rough first game for the Broncos’ of

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