The drama continues as the 2025 Week 2 NFL schedule features a number of intriguing matchups, including a rematch of Super Bowl LIX when the Philadelphia Eagles take on the Chiefs (+1) at Kansas City. Other heavyweight matchups include Commanders vs. Packers (-3.5) on Thursday; Broncos vs. Colts (+2.5), Bears vs. Lions (-4.5) and Giants vs. Cowboys (-6) on Sunday; and Buccaneers vs. Texans (-2.5) and Chargers vs. Raiders (+3.5) on Monday night. The game with the largest spread on the Week 2 NFL odds board is Browns vs. Ravens (-12.5) on Sunday.

Who should you back in each of the games on the remaining Week 2 NFL schedule, and how should you handle all your NFL money line, NFL over/under and NFL against the spread spread picks? Before making any Week 2 NFL picks or Week 2 NFL score predict

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