Signs of early immune aging appear in those at risk of rheumatoid arthritis (RA) before the disease fully develops , suggesting that these changes caught sooner could contribute to the start of the condition, according to a new study published in The Lancet’s eBioMedicine.

Rheumatoid arthritis is a chronic autoimmune disease that becomes more common with age, but researchers are still attempting to understand how aging processes influence its development. Typically, the immune system remodels gradually over time, leaving folks more vulnerable to infections and less responsive to vaccines.

However, this remodeling seems to occur much earlier.

Patients often show signs such as thymic shrinkage, shortened telomeres in immune cells and imbalances between regulatory and inflammatory T cel

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