Under Kyle Shanahan, the San Francisco 49ers have tended to either dominate as NFC contenders or succumb to a rash of season-crushing injuries. And the 2025 campaign just might be continuing that trend for the worse.

After a summer littered with questions about the availability of wide receivers like Brandon Aiyuk , who's still recovering from a 2024 knee injury, the 49ers are now set to be without arguably their next two most important players. Quarterback Brock Purdy and tight end George Kittle both suffered injuries in Week 1's win over the Seattle Seahawks , and both Pro Bowlers are expected to miss multiple weeks of action.

Purdy is on track to be sidelined anywhere from two to five weeks while nursing a variation of turf toe, per NFL Media , while Kittle just landed on

See Full Page