The Colorado Buffaloes (1-1) travel to take on the Houston Cougars (2-0) on Friday in the Big 12 opener for both teams. The Buffs are coming off a solid 31-7 win over Delaware in their last outing. Head coach Deion Sanders named sophomore Ryan Staub the team's starting quarterback for this game. Houston is looking to build off its 35-9 win over Rice and move to 3-0 on the season. The Cougars are led by junior quarterback Conner Weigman.

Kickoff is set for 7:30 p.m. ET at TDECU Stadium in Houston. The Cougars are 4-point favorites in the latest Colorado vs. Houston odds, while the over/under for total points scored is 45.5. Before making any Houston vs. Colorado picks, be sure to see what SportsLine expert Jimmie Kaylor has to say .

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