The San Francisco 49ers will face the New Orleans Saints in Week 2 of the NFL season on Sunday at the Caesars Superdome.

How to Watch 49ers vs Saints

Date: Sunday, September 14, 2025

Time: 1:00 PM ET

Channel: FOX

Stream: Fubo ( try for free )

The 49ers are already the most banged-up team in the league, and will be without their star tight end, George Kittle, for at least four weeks, while starting quarterback Brock Purdy could also miss several weeks. San Francisco seems to get hit the hardest with the injury bug every season, but when healthy, they have the talent to be a true contender. They will look to escape with their second win of the season despite being short-handed.

The Saints project to be one of the worst teams in the NFL this year, and while they did not have th

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