Early in the Covid-19 pandemic, a severe post-infectious complication of SARS-CoV-2 emerged globally called multisystem inflammatory syndrome in children (MIS-C) , affecting mostly previously healthy children of school age. The great majority of these children were admitted to the intensive care unit, not due to pneumonia, but because of life-threatening cardiovascular involvement including myocarditis. CDC investigators were tracking MIS-C closely in national surveillance networks and through collaboration with state public health reporting. As of Sept. 2, 2025 there have been 9,783 cases of Covid-19-related cases of MIS-C in the U.S., including 80 deaths reported to the CDC.

Once clinical trials showed that Covid-19 vaccines were safe and effective in children and the FDA grant

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