The San Francisco 49ers battle the Arizona Cardinals in their home opener at Levi’s Stadium on Sunday, Sept. 21 at 1:25 p.m. PDT.

The Niners are coming off consecutive road victories to open the season, including a 26-21 win in New Orleans with backup quarterback Mac Jones directing the offense.

Arizona comes in at 2-0 on the season, as well, after beating the Saints and Panthers.

Brock Purdy just may make his return for the 49ers as he returned to practice this week.

How to watch on local TV

FOX is broadcasting the game in California; in the Bay Area, tune in to KTVU-TV (channel 2) with an antenna or a cable TV provider. You can also log in to the FOX Sports app or website with your cable TV subscription credentials.

How to stream

DirecTV Stream includes Fox in its lo

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