President Donald Trump is picking off international drug traffickers again ... he ordered the deadly strike of a vessel he says was packed with illegal narcotics.

47 jumped on Truth Social Friday night to boast about his third strike in recent memory on boats transporting drugs like fentanyl into the United States through international waters.

Check out video of the strike ... it's quite the eye-popper.

In his Truth Social post, Trump wrote ... on his orders, the Secretary of War directed a "lethal kinetic strike on a vessel affiliated with a Designated Terrorist Organization" that was trafficking illicit drugs in the U.S. Southern Command, which is responsible for operations mainly in the region of South America and the Caribbean.

Donald said the vessel was traveling in waters kno

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