LA Rams at Philadelphia Eagles odds, picks and predictions

Los Angeles Rams quarterback Matthew Stafford (9) drops back to pass Tennessee Titans during the first half at Nissan Stadium in Nashville, Tennessee.

The LA Rams (2-0) are visiting the Philadelphia Eagles (2-0) Sunday for a rematch of their playoff game in January. Kickoff from Lincoln Financial Field in Philadelphia, Pennsylvania, is set for 1 p.m. ET (FOX). Let's analyze BetMGM Sportsbook's NFL odds around the Rams vs. Eagles odds and make our expert NFL picks and predictions for the best bets.

The Rams are 2-0 to start the year for the first time since 2021. They beat the Houston Texans, 14-9, in a defensive slugfest in the season opener, and then took down the Tennessee Titans, 33-19, in Week 2. LA leads the league in points allowed (28) this season, while also ranking 11th in points scored. The Rams have looked like one of the best teams in the NFC thus far but will be tested against the undefeated Eagles Sunday.

Also at 2-0, the Eagles knocked off 2 quality opponents in the first 2 weeks: The Dallas Cowboys and Kansas City Chiefs. Despite ranking 29th in total yards, the Eagles are still 16th in points scored and, defensively, they've allowed the 12th-fewest points in the league. They've lost just 1 game since Week 7 of last season and come in as one of the favorites to win it all in 2025.

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Rams at Eagles odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Saturday at 4:06 p.m. ET.

Moneyline (ML): Rams +155 (bet $100 to win $155) | Eagles -190 (bet $190 to win $100)
Against the spread (ATS): Rams +3.5 (-115) | Eagles -3.5 (-105)
Over/Under (O/U): 44.5 (O: -110 | U: -110)

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Rams at Eagles key injuries

Rams

LG Steve Avila (ankle) doubtful
DT Braden Fiske (oblique) questionable
TE Colby Parkinson (shoulder) questionable
CB Ahkello Witherspoon (shoulder) injured reserve

Eagles

None

Rams at Eagles picks and predictions

Prediction

Rams 24, Eagles 23

Moneyline

The Rams are well-positioned to pull off the upset here. Their run defense has improved thanks to the additions of LB Nate Landman and NT Poona Ford, which should help them keep RB Saquon Barkley in check after he rushed for 460 yards and 4 touchdowns in 2 games against the Rams last year.

WR Davante Adams also makes their offense much more dynamic and vertical, while C Coleman Shelton will be an upgrade over C Beaux Limmer when it comes to protecting QB Matthew Stafford. As long as the Rams can limit the long runs by Barkley, they'll have a great chance to win Sunday.

BET RAMS (+155) on the moneyline to upset the Eagles on the road.

Against the spread

Since we're already taking the Rams on the moneyline, it doesn't make a whole lot of sense to also bet them with the points. It can be a way to guard against a close loss, but in each of their games against the Eagles last season, they lost by at least 6 points.

PASS on the spread if you're also taking them on the ML.

Over/Under

The Eagles play a methodical and boring style of offense, running the ball and milking the clock; they're second in time of possession and 29th in total yards. What could speed up their tempo is an early Rams lead, which is possible given how good Sean McVay is at scripting games.

The Over/Under of 44.5 points isn't terribly high for 2 teams with as much offensive talent as they have, so we like the OVER 44.5 (-110) in this one.

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This article originally appeared on Sportsbook Wire: LA Rams at Philadelphia Eagles odds, picks and predictions

Reporting by Cameron DaSilva, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect