Undefeated NFC West rivals square off in Week 3 NFL action as the San Francisco 49ers host the Arizona Cardinals . Kyler Murray and the Cardinals face their first division rival of the season after kicking off the 2025 campaign with wins against the New Orleans Saints and the Carolina Panthers. The 49ers head into their home opener with gritty wins against the Seattle Seahawks and the Saints, but quarterback Brock Purdy (shoulder/toe) is not expected to be under center.

Kickoff from Levi's Stadium is set for 4:25 p.m. ET. San Francisco is a 2.5-point favorite in the latest Cardinals vs. 49ers odds from SportsLine consensus, while the over/under for total points scored is 44.5. The 49ers are -150 money line favorites (risk $150 to win $100), while the Cardinals are +126 underdogs. Befo

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