There is a high demand for safe and long-lasting medications to treat bone loss for the millions of people with osteoporosis.

Discovering new targets for drug development is therefore a key step towards better therapies.

In a recent study, scientists at Leipzig University in Germany demonstrated that the G protein receptor called GPR133 plays a central role in building and maintaining healthy bone

“If this receptor is impaired by genetic changes, mice show signs of loss of bone density at an early age—similar to osteoporosis in humans,” explains Professor Ines Liebscher, lead investigator of the study published in Nature.

The team was able to significantly increase bone strength in both healthy and osteoporotic mice using the substance AP503, which was recently identified as a stimul

See Full Page