The San Francisco 49ers have dealt with several injuries this season, and another one has popped up against the Arizona Cardinals. This time, it's Nick Bosa , and it doesn't seem like it's good . Bosa was seen giving a thumbs down after leaving the medical tent on his way to the locker room, according to NFL Network's Tom Pelissero.

Bosa was seen testing out his knee, but it must have been something he couldn't play through at the time. All eyes will be on Bosa to see if he returns during the game.

Bosa did not return to the game and was ruled out by the team shortly after the second half started.

During training camp, Bosa missed some time because of some soreness, but he was able to return and has played in all three games this season. Bosa also wasn't the only defender who

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