NICK BOSA was the latest big-name linebacker to receive a significant injury.

After Khalil Mack went down in Week 2, San Francisco 49ers star Bosa left the game against the Arizona Cardinals with a bad knee injury.

More news will come in the next couple of days but Kyle Shanahan did not rule out the possibility of an ACL injury in the immediate aftermath.

Other big time injuries saw a pair of star NFC East receivers leave the field.

CeeDee Lamb and Terry McLaurin both went down in Week 3 as we await an update on their status.

Mike Evans was another big-name receiver who left his game, the Tampa Bay Buccaneers star pulling up with an apparent hamstring injury.

The Los Angeles Chargers, who lost Mack last week, saw Najee Harris seemingly injure his Achilles, which could be a season end

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