New York Yankees designated hitter Aaron Judge (99) reacts after New York Yankees first base Ben Rice (not pictured) sixth inning rbi single from second base against the Baltimore Orioles at Oriole Park at Camden Yards in Baltimore, Maryland.

The Chicago White Sox (58-98) and the New York Yankees (88-68) open a 3-game series Tuesday at Yankee Stadium in the Bronx, New York. First pitch is scheduled for 7:35 p.m. ET. Let's analyze BetMGM Sportsbook's MLB odds around the White Sox vs. Yankees odds and make our expert MLB picks and predictions for the best bets.

Season series: Yankees lead 3-1

The White Sox have been eliminated from the postseason for some time, and Chicago’s goal is simply to avoid losing 100 games. While it dropped the first 3 contests of a 4-game set in Chicago Aug. 28-31, it won 3-2 in the series finale. Still, Chicago is just 2-8 in the past 10 tries against New York.

Chicago lost 3-2 to San Diego at home Sunday, dropping the interleague series with 2 losses in 3 tries. It is also 1-8 in the past 9 games since Sept. 12, with the Under going 8-2 across the past 10 outings. In Sunday's loss to the Padres, 3B Miguel Vargas and OF Andrew Benintendi provided the RBIs.

The Yankees are in position for a Wild Card spot, and they can clinch a postseason berth with a victory Tuesday. New York has won 5 of the past 6 games, including winning 3 of 4 from the Baltimore Orioles over the weekend.

In Sunday's 7-1 win over the O's, New York cashed as a moderate favorite (-130) as the Under (8.5) hung on. 1B-C Ben Rice was the big bat in the lineup, going 4-for-5 with a double, a home run and 5 RBIs. All-Star 2B Jazz Chisholm Jr. also went 1-for-4 with a solo homer and a walk.

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White Sox at Yankees projected starters

RHP Shane Smith vs. RHP Luis Gil

Smith (6-8, 4.06 ERA) makes his 28th start. The rookie has a 1.22 WHIP, 3.6 BB/9 and 8.6 K/9 through 135 1/3 innings.

  • Last start: Loss, 4 1/3 IP, 6 ER, 9 H, 1 HR, 1 BB, 7 K in 8-7 home setback to Orioles Sept. 16
  • Last 7 games: 3-1, 3.66 ERA (39 1/3 IP, 16 ER), 1.04 WHIP, 8.2 K/9
  • 2025 road stats: 3-4, 4.59 ERA (64 2/3 IP, 33 ER), 1.33 WHIP, 10 HR, 9.0 K/9 in 13 starts
  • Career vs. Yankees: 1 home start (Aug. 30), no-decision, 6 1/3 IP, 2 ER, 3 H (2 solo HR), 2 BB, 7 K in 5-3 defeat in 11 innings

Gil (4-1, 3.33 ERA) makes his 10th start. He has a 1.50 WHIP, 5.7 BB/9 and 7.0 K/9 through 46 innings.

  • Last start: No-decision, 4 2/3 IP, 4 ER (5 R), 9 H, 2 BB, 2 K in 10-5 victory at Minnesota Twins Wednesday
  • Last 7 games: 4-0, 2.41 ERA (37 1/3 IP, 10 ER), 1.42 WHIP, 6.3 K/9
  • 2025 home stats: 2-0, 2.11 ERA (21 1/3 IP, 5 ER), 1.50 WHIP, 1 HR, 14 BB, 16 K in 4 starts
  • 2025 vs. White Sox: 1 road start (Aug. 31), no-decision, 5 1/3 IP, 2 ER, 4 H (1 HR), 2 BB, 8 K in 3-2 setback
  • Career vs. White Sox: 1-1, 5.12 ERA (19 1/3 IP, 11 ER), 1.45 WHIP, 2 HR, 7 BB, 29 K in 4 starts

White Sox at Yankees odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:16 a.m. ET.

  • Moneyline (ML): White Sox +200 (bet $100 to win $200) | Yankees -250 (bet $250 to win $100)
  • Run line (RL)/Against the spread (ATS): White Sox +1.5 (+100) | Yankees -1.5 (-120)
  • Over/Under (O/U): 9 (O: -105 | U: -115)

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White Sox at Yankees picks and predictions

Prediction

Yankees 5, White Sox 3

Moneyline

The Yankees (-250) will cost you 2½ times your potential return, and that's way too expensive for a singular wager. Even as part of a multi-leg parlay, including New York decreases the value of your betslip substantially.

AVOID, and look to the run line instead.

Run line/Against the spread

A better play is backing YANKEES -1.5 (-120) on the run line in this potential playoff-clinching spot.

It won’t be easy for New York. While it is playing for something and Chicago is playing for pride, the White Sox do have an All-Star on the mound. However, Gil has pitched very well lately, and he is the unlikely starter who will pitch the Bronx Bombers into the postseason.

Over/Under

UNDER 9 (-115) is worth playing lightly, but go with a half-unit play at best.

The Under has cashed in 4 in a row for the Yankees, while it is 4-4 in the past 8 games at The Stadium. The total went low in the 2 most recent meetings against the White Sox, too.

For the Pale Hose, the Under has cashed in 8 of the past 10 games, while hitting in each of the past 3 on the road, and 4 of the past 5 away from home. The Under hit in Smith's start against the Yankees Aug. 30, and in Gil's start against the White Sox Aug. 31, too.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Chicago White Sox at New York Yankees odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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