Long-term adaptive deep brain stimulation (aDBS) at home compares favorably to the standard of care for patients with Parkinson’s disease, a pivotal clinical trial indicates.

Researchers report that the tailored therapy, which automatically adjusts the amplitude of stimulation in response to changes in relevant neural activity, was tolerable, effective, and safe compared with continuous (c)DBS when each was combined with medication.

“Delivering adaptive neurostimulation chronically, in response to a personalized neural physiomarker, is both technically and clinically possible, laying the foundation for the wider clinical application of aDBS,” reported Helen Bronte-Stewart, MD, from Stanford University, and co-workers.

Results from the international, multicenter Adaptive DBS Algorithm fo

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