Seven New Orleans Saints players were listed on Wednesday's Injury Report for the team's Week 4 game against the Buffalo Bills during the 2025 NFL season.

NEW ORLEANS SAINTS Position Name Injury Wednesday OL Dillon Radunz Toe DNP DE Chase Young Calf DNP T Taliese Fuaga Knee/Back LP WR Trey Palmer Hamstring LP WR Devaughn Vele Hip LP DE Cameron Jordan Groin FP T/G Trevor Penning Toe FP

BUFFALO BILLS Position Name Injury Wednesday OL Spencer Brown Calf DNP LB Matt Milano Pectoral DNP DT Ed Oliver Ankle DNP DE AJ Epenesa Pectoral LP

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