Seattle Seahawks quarterback Sam Darnold (14) throws the ball during the first quarter against New Orleans Saints at Lumen Field in Seattle, Washington.

The Seattle Seahawks (2-1) visit the Arizona Cardinals (2-1) Thursday night to kick off Week 4. Kickoff from State Farm Stadium in Glendale, Arizona, is set for 8:15 p.m. ET (Prime Video). Let's analyze BetMGM Sportsbook's Seahawks vs. Cardinals odds and tab the 5 best prop bets to win among SportsbookWire's expert NFL picks and predictions for Week 4.

The Seahawks have won 2 games in a row after a season-opening 17-13 loss to the San Francisco 49ers. They are coming off a 44-13 blowout win over the New Orleans Saints in Week 3 as 7.5-point favorites. The Over (42) cashed. QB Sam Darnold has 4 TD passes and 2 INTs in 3 games. The Seahawks are fifth in scoring, averaging 29.3 points per game (PPG), and second in points allowed, giving up 15.7 PPG.

The Cardinals started the season 2-0 but lost 16-15 to the San Francisco 49ers Sunday, covering as 2-point underdogs. The Under (44.5) cashed. QB Kyler Murray has thrown 4 TD passes and 1 pick through 3 games. The offense is struggling to score, averaging 20.7 PPG, good for 19th in the league, but the defense is much improved over 2024, allowing 17.0 PPG, good for fifth in the league.

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Best Seahawks at Cardinals prop bets

Odds provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Wednesday at 6:50 p.m. ET.

Cardinals QB Kyler Murray OVER 28.5 RUSHING YARDS (-115)

Murray has not had a big rushing game yet, but he has rushed for between 32 and 38 yards in 3 straight games and has surpassed 26 yards in 5 of his last 6 games, dating back to last season.

Seahawks WR Jaxon Smith-Njigba OVER 81.5 RECEIVING YARDS (-115)

Smith-Njigba averages 107.7 receiving yards per game and has had no fewer than 96 in a game this season. The Cardinals allowed Carolina Panthers WR Tetairoa McMillan and San Francisco 49ers WR Ricky Pearsall to reach 100 receiving yards in the last 2 games. Over 80.5 yards seems like a lock, while adding 100+ alternate receiving yards at +140 odds is also a good play.

Cardinals PK Chad Ryland OVER 1.5 FIELD GOALS MADE (-140)

Ryland has made 2 field goals in all 3 games this season. Dating back to last season, he has 4 consecutive games with at least 2 made field goals. He has made 2 or more field goals in 6 of his last 7 games and 12 of his last 15.

Cardinals RB Trey Benson OVER 3.5 RECEPTIONS (+105)

Benson takes over the No. 1 running back role after James Conner suffered a season-ending foot injury in Week 3. The Seahawks allow only 3.2 yards per rushing attempt, and the Cardinals' passing game relies on quick, short throws. Expect Benson to get opportunities in the pass game.

Seahawks QB Sam Darnold OVER 0.5 INTERCEPTIONS THROWN (+100)

Darnold's 2 INTs this season came in Week 2. Last season with Minnesota, he threw interceptions in 5 of the first 6 games and in 7 of his first 9. The Cardinals have recorded an interception in 2 straight games.

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This article originally appeared on Sportsbook Wire: Seattle Seahawks at Arizona Cardinals best prop bets for Thursday Night Football

Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire

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