A particular immune system signature present in the antibodies of some people could leave them at increased risk of dengue fever after vaccination, researchers reported.

The findings, in Science Translational Medicine , demonstrated how both the quality and quantity of antibodies generated by vaccines can affect their effectiveness.

The study found that people with a particular modification in their immunoglobulin (IgG) antibodies were susceptible to reinfection. The research highlights immune factors that could be targeted in future vaccine strategies for both dengue and other diseases.

“Overall, these findings emphasize the importance of considering both neutralizing and non-neutralizing antibody characteristics in vaccine development and evaluation,” summarized Usama Ashraf, PhD,

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