Georgia wide receiver Dillon Bell (86) fights off the tackle of Alabama defensive back Keon Sabb (3) during the fourth quarter at Bryant-Denny Stadium.

Our panel of pigskin prognosticators will have its work cut out this week with a slew of marquee matchups on the college football slate.

The prime-time headliner Saturday night features No. 2 Penn State hosting No. 5 Oregon, but that’s not the only important matchup in the Big Ten. No. 1 Ohio State leaves home for the first time to take on unbeaten Washington, No. 12 Indiana heads to Iowa, and No. 22 Southern California ventures east to No. 23 Illinois. Not to be outdone, the SEC has a couple of ranked contests as No. 3 Georgia hosts No. 16 Alabama and No. 4 LSU visits No. 11 Mississippi.

The weekend even gets an early start with a pair of games involving Top 25 squads on Friday night. The evening begins with an ACC tilt as No. 8 Florida State visits Virginia, then in Big 12 territory No. 25 TCU puts its newfound spot in the poll on the line at Arizona State.

Who will come out on top in those games, and where else might there be upsets? Here’s what our experts think.

College football picks for Week 5

This article originally appeared on USA TODAY: College football Week 5 picks, predictions include Alabama-Georgia, Oregon-Penn State

Reporting by Eddie Timanus, USA TODAY / USA TODAY

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