Seattle Seahawks quarterback Sam Darnold (14) throws the ball during the first quarter against New Orleans Saints at Lumen Field in Seattle on Sept. 21, 2025.

All four NFC West teams have a winning record entering Week 4 of the 2025 NFL season. That will change as the Arizona Cardinals host the Seattle Seahawks on "Thursday Night Football."

The Cardinals (2-1) are fresh off their first loss of the season, a 16-15 defeat at the hands of the San Francisco 49ers. Arizona had a two-point lead in the fourth quarter of the defensive battle but allowed Mac Jones to lead a game-winning drive that was capped off by an Eddy Pineiro field goal as time expired.

Now, the Cardinals are looking to bounce back on the short week after losing their top running back, James Conner, to a season-ending ankle injury. Trey Benson will step into that role while Jonathan Gannon's defense will look to remain strong against the run after allowing the fourth-fewest rushing yards to opponents over the first few weeks.

If Arizona can succeed in limiting Seattle's Kenneth Walker-led rushing attack, that will put the onus on Sam Darnold to carry the Seahawks offense. Darnold has performed well to start the season, completing 70.3% of his passes with a 104.7 passer rating (eighth-best in the NFL) and has thrown multiple touchdowns in back-to-back games.

Seattle's defense will also be critical in helping Mike Macdonald's team remain competitive on the road. The unit is allowing just 15.7 points per game to start the season, the second-fewest in the NFL. The Seahawks could make life difficult on Kyler Murray if they can continue to get pressure at a solid clip.

Here's what to know about the Cardinals vs. Seahawks "Thursday Night Football" matchup for NFL Week 4.

What time does Cardinals-Seahawks NFL game start?

The Cardinals vs. Seahawks game will kick off at 8:15 p.m. ET on Thursday, Sept. 25. The game will be played at State Farm Stadium in Glendale, Ariz. and will mark the third official "Thursday Night Football" broadcast of the 2025 NFL season.

What channel is Arizona Cardinals vs Seattle Seahawks on tonight?

The Arizona Cardinals vs. Seattle Seahawks game will be broadcast on Amazon Prime, which owns the broadcast rights to the NFL's "Thursday Night Football" package for 2025. Al Michaels (play-by-play), Kirk Herbstreit (game analyst) and Kaylee Hartung (sideline reporter) will be on the call for the game.

Viewers watching the game nationally will need to have an Amazon Prime subscription to access the game feed. Those in the local markets of each team – Arizona and Seattle – will also be able to watch a simulcast of the game on local TV stations as part of the NFL's agreement with the streaming giant.

Below is a look at the local channels that will air the contest:

  • Arizona: KSAZ (Fox 10)
  • Seattle: KCPQ (Fox 13)

Watch "Thursday Night Football" with a Prime Video subscription

2025 Arizona Cardinals schedule

Arizona Cardinals record 2025

  • Arizona Cardinals: 2-1; tied for second place in NFC West.

2025 Seattle Seahawks schedule

Seattle Seahawks record 2025

  • Seattle Seahawks: 2-1; tied for second place in NFC West.

2025 NFL team schedules: complete team-by-team schedule of games

  • AFC East: Buffalo Bills − Schedule | Miami Dolphins − Schedule | New England Patriots − Schedule | New York Jets − Schedule
  • AFC North: Baltimore Ravens − Schedule | Cincinnati Bengals − Schedule | Cleveland Browns − Schedule | Pittsburgh Steelers − Schedule
  • AFC South: Houston Texans − Schedule | Indianapolis Colts − Schedule | Jacksonville Jaguars − Schedule | Tennessee Titans − Schedule
  • AFC West: Denver Broncos − Schedule | Kansas City Chiefs − Schedule | Las Vegas Raiders − Schedule | Los Angeles Chargers − Schedule
  • NFC East: Dallas Cowboys − Schedule | New York Giants − Schedule | Philadelphia Eagles − Schedule | Washington Commanders − Schedule
  • NFC North: Chicago Bears − Schedule | Detroit Lions − Schedule | Green Bay Packers − Schedule | Minnesota Vikings − Schedule
  • NFC South: Atlanta Falcons − Schedule | Carolina Panthers − Schedule | New Orleans Saints − Schedule | Tampa Bay Buccaneers − Schedule
  • NFC West: Arizona Cardinals − Schedule | Los Angeles Rams − Schedule | San Francisco 49ers − Schedule | Seattle Seahawks − Schedule

Complete 2025 NFL regular season schedule: every team's games, week-by-week

This article originally appeared on USA TODAY: What channel is Cardinals vs Seahawks game on today? Start time, schedule, streaming

Reporting by Jacob Camenker, USA TODAY / USA TODAY

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