Arizona Cardinals quarterback Kyler Murray (1) takes the field before their game against the Carolina Panthers at State Farm Stadium on Sept 14, 2025.

The NFL season is in full swing and the next edition of "Thursday Night Football" features a massive divisional showdown to kick off Week 4.

The Seattle Seahawks (2-1) travel to the desert to battle the Arizona Cardinals (2-1).

Through three weeks, the NFC West is the class of the league, with all four teams boasting a winning record. It's a bit early to be discussing "must-win" games but with the San Francisco 49ers (3-0) leading the division and the Los Angeles Rams (2-1) also off to a good start, there's a small margin for error for both sides tonight.

The Seahawks' lone loss came at the hands of the 49ers in Week 1, but they've bounced back with impressive wins against the Pittsburgh Steelers and New Orleans Saints. Free agent signee Sam Darnold and wide receiver Jaxon Smith-Njigba spearhead Seattle's offense. However, their running game has been inefficient, averaging the fourth-fewest yards per carry.

The Cardinals' loss was also against the 49ers last Sunday. Arizona received a massive blow in the game when starting running back James Conner suffered a foot injury that will end his season.

With the help of tight end Trey McBride and second-year wideout Marvin Harrison Jr., quarterback Kyler Murray will look to produce through the air while Trey Benson will step into a premier role out of the backfield. Benson – also a second-year player – has big shoes to fill as Conner surpassed 1,000 rushing yards in each of the last two seasons. He'll have his hands full against the Seahawks front-seven who have allowed just 3.2 yards per rush - the third-best in the NFL.

Arizona's defense has also been a strength allowing 17 points per game this season – fifth-fewest in the NFL. They will hope to dry up Seattle's offense in the desert tonight.

USA TODAY Sports will provide live updates, highlights and more from the Week 4 matchup between the Cardinals and Seahawks below.

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What time does Cardinals vs. Seahawks start?

  • Kickoff time: 8:15 p.m. ET | 5:15 p.m. PT

The Seattle Seahawks travel to State Farm Stadium in Glendale, Arizona to take on the Cardinals at 8:15 p.m. ET on Thursday night.

What TV channel is Cardinals vs. Seahawks on today?

  • TV channel (Seattle market): Fox 13
  • TV channel (Phoenix market): Fox 10

The game will be broadcast on TV locally for those in the Seattle and Phoenix TV markets.

For those in the Cardinals TV market, the game will be broadcast on Fox 13.

Cardinals vs. Seahawks live stream

  • Live stream: Amazon Prime Video

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Cardinals vs. Seahawks prediction

Thursday night matchups tend to be difficult for teams to prepare for and often result in some unattractive performances. With this being a divisional clash between the Cardinals and Seahawks, it could end up being a lackluster clash. Both teams rank inside the top five in scoring defense and have been terrific at stopping their opponents in the red zone. Both sidelines feature defensive head coaches in Mike Macdonald (Seahawks) and Jonathan Gannon (Cardinals).

Seattle has allowed the second-fewest points per game, and they get reinforcements in the form of Julian Love and Devon Witherspoon in the secondary tonight. The Seahawks will take down the Cardinals on the road in a low-scoring affair.

Prediction: Seahawks 20, Cardinals 17

Cardinals vs. Seahawks odds

Kyler Murray arrives for tonight's game vs. Seahawks

The Cardinals quarterback has arrived at the stadium alongside guard Will Hernandez.

Cardinals vs. Seahawks injury report

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NFC West division standings

  • San Francisco 49ers: 3-0
  • Arizona Cardinals: 2-1
  • Seattle Seahawks: 2-1
  • Los Angeles Rams: 2-1

Super Bowl odds

  • 1. Buffalo Bills (+425)
  • 2. Baltimore Ravens (+550)
  • T3. Green Bay Packers (+750)
  • T3. Philadelphia Eagles (+750)
  • 4. Detroit Lions (+1000)
  • 5. Kansas City Chiefs (+1400)
  • 6. Los Angeles Chargers (+1500)
  • 7. San Francisco 49ers (+1600)
  • 8. Los Angeles Rams (+2000)
  • T9. Tampa Bay Buccaneers (+2200)
  • T9. Washington Commanders (+2200)

Cardinals inactives vs. Seahawks

Seahawks inactives vs. Cardinals

Arizona Cardinals 2025 schedule

Seahawks 2025 schedule

Cardinals vs. Seahawks best bets, player props

Analysis of four player prop bets for "Thursday Night Football" - from Jacob Camenker

  • Trey Benson 25+ receiving yards (-105)
  • Trey McBride OVER 6.5 receptions (+100)
  • Sam Darnold OVER 220.5 passing yards (-115)
  • Kyler Murray anytime TD scorer (+275)

James Conner injury update

Conner suffered a season-ending foot injury against the 49ers in Week 3.

Head coach Jonathan Gannon confirmed that the injury would require surgery and sideline the running back for the remainder of the season. It was initially called an ankle injury for Conner, but Gannon confirmed that it was the running back's foot. - Nick Brinkerhoff

Who are the 'Thursday Night Football' announcers for Amazon Prime Video?

Al Michaels (play-by-play) and Kirk Herbstreit (analyst) will be in the broadcast booth for Prime Video, with Kaylee Hartung (sideline) and Terry McAulay (rules analyst) providing additional coverage.

The Prime Video pregame, halftime and postgame shows feature Charissa Thompson as host, as well as former NFL players Ryan Fitzpatrick, Tony Gonzalez, Richard Sherman and Andrew Whitworth as analysts.

Taylor Rooks is the feature reporter for Prime Video's "Thursday Night Football" coverage.

This article originally appeared on USA TODAY: Cardinals vs. Seahawks live updates, inactives, start time, TV channel for NFL Week 4 game

Reporting by Tom Viera, USA TODAY / USA TODAY

USA TODAY Network via Reuters Connect