Sam Darnold and the Seattle Seahawks (2-1) visit the Arizona Cardinals (2-1) to kick off NFL Week 4 with Thursday Night Football on September 25 (9/25/2025) at 8:15 p.m. ET. It looks like a tight contest with an early season lead on the line, so here’s what you need to know to watch.

Darnold, who signed a three-year contract worth up to $100.5 million in the offseason, is looking the part of a franchise quarterback. He’s completed 70.3% of his passes (sixth best in the league), and is helping the Seahawks move the ball while figuring out the run game. But their up against Kyler Murray and a hungry Cardinals side trying to bounce back from a 16-15 heartbreaker against the 49ers.

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