Sep 20, 2025; Tallahassee, Florida, USA; Florida State Seminoles quarterback Thomas Castellanos (1) during the first half against the Kent State Golden Flashes at Doak S. Campbell Stadium. Mandatory Credit: Melina Myers-Imagn Images

Friday night in the ACC gives the college football world a matchup from Scott Stadium in Charlottesville, Virginia, when the 3-1 Virginia Cavaliers welcome in the rejuvenated Florida State Seminoles, who are 3-0.

Florida State looks refreshed after a disastrous 2024 and has made a lot of noise early in the season. The Virginia Cavaliers are 3-1 and have their sights set on an upset over Florida State, which could change the trajectory of their entire season.

If you are looking for some betting advice for the matchup, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Stream Florida State vs. Virginia

Florida State vs. Virginia game odds

All college football odds via BetMGM

  • Spread: Florida State -7 (-105), Virginia +7 (-115)
  • Money Line: Florida State -250, Virginia +200
  • Over-Under: Over 59.5 (-115), Under 59.5 (-105)

Florida State vs. Virginia prediction, pick:

The 2024 Florida State Seminoles falter in this game and get stuck in a dogfight on a Thursday night ACC matchup. This is 2025, and the Seminoles are a different team. They don't mess around in this game.

Despite the road game and what is sure to be a hostile environment at kickoff, Virginia is not on the same talent level as Florida State. They are 3-1, but those wins are against Coastal Caroline, William and Mary, and Stanford. Not exactly murder's row. They lost to NC State in Week 2.

Thomas Castellanos is probable to play in this game, and that ignites the Seminoles' offense, which has proven their success running or throwing. Virginia has been just fine on defense, but it does give up some yards and points. That gives Florida State enough room to work.

Prediction: Florida State 31, Virginia 21

Best Bet: Florida State -7

Florida State vs. Virginia channel, start time, streaming:

Time: 7 p.m. ET

TV Channel: ESPN

Live Stream: ESPN App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Florida State vs. Virginia: Week 5 College Football Betting Odds, Prediction, Pick

Reporting by Riley Donald, College Sports Wire / College Sports Wire

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