This weekend, a pair of longtime SEC rivals will meet up with more than just bragging rights on the line.

No. 4 LSU and No. 11 Ole Miss will put their undefeated records on the line when the Tigers travel to Vaught-Hemingway Stadium in Oxford, Mississippi, on Saturday, Sept. 27 in one of the biggest, potentially most-consequential matchups of the young 2025 college football season.

Stream LSU vs. Ole Miss live with Fubo (free trial)

In its fourth season under coach Brian Kelly, LSU has established itself as a College Football Playoff contender, with wins against then-No. 6 Clemson and Florida already on its resume. Quarterback Garrett Nussmeier has largely lived up to his immense preseason hype, with 962 yards, six touchdowns and two interceptions. He's been complemented by a vicious defense under second-year coordinator Blake Baker that hasn't allowed more than 10 points in a game this season.

The Tigers will get their stiffest challenge yet in the Rebels, who continue to be among the most explosive teams in the country under coach Lane Kiffin. In its four wins, Ole Miss has averaged 44.8 points per game, the 12th-most among 136 FBS teams. It will look to continue that momentum with quarterback Trinidad Chambliss, who will reportedly be getting the start under center. In wins against Arkansas and Tulane, Chambliss completed 38 of his 56 passes (67.9%) for 660 yards, three touchdowns and no interceptions while adding 174 yards and two touchdowns on the ground.

LSU has won seven of the past nine meetings, though Ole Miss won a 55-49 thriller in Oxford in 2023 in the most recent matchup between the programs.

Here’s how to watch the LSU vs. Ole Miss game during Week 5 of the 2025 college football season, including the TV channel, start time, streaming information and more:

What channel is LSU vs Ole Miss on today?

  • TV channel: ABC
  • Live stream: ESPN app ∣ ESPN+ ∣ Fubo (free trial)

LSU vs. Ole Miss will air nationally on ABC in Week 5 of the 2025 college football season. Sean McDonough (play-by-play) and Greg McElroy (analyst) will call the game from the booth at Vaught-Hemingway Stadium while Molly McGrath will serve as the sideline reporter.

Streaming options for the matchup include the ESPN app, which requires a valid cable login to access; ESPN+, ESPN's subscription streaming service; and Fubo, which offers a free trial to potential subscribers.

LSU vs Ole Miss time today

  • Date: Saturday, Sept. 27
  • Start time: 3:30 p.m. ET

The game between the Tigers and Rebels is scheduled to kick off at 3:30 p.m. ET on Sept. 27 from Vaught-Hemingway Stadium in Oxford, Mississippi.

LSU vs Ole Miss predictions, picks, odds

Odds courtesy of BetMGM as of Wednesday, Sept. 24.

  • Spread: Ole Miss -1.5
  • Over/under: 54.5 points
  • Moneyline: Ole Miss -120 ∣ LSU +100

Prediction: LSU 27, Ole Miss 24

The two Power Four offenses LSU has faced this season, Clemson and Florida, haven't exactly been lighting up scoreboards, but LSU's defense has been superb, allowing just 9.3 points per game in four games. It won't slow down Ole Miss in the same way, but it'll be enough to get out of Oxford with a win.

This article originally appeared on USA TODAY: What channel is LSU vs Ole Miss on today? Time, TV schedule for Week 5 game

Reporting by Craig Meyer, USA TODAY NETWORK / USA TODAY

USA TODAY Network via Reuters Connect