‘General Hospital’ Cast Changes as of September 2025: Multiple Stars Exited, Several Joined, & Fan-Favorites Return (See the Latest Updates!) | ABC, Casting, EG, Extended, General Hospital, Slideshow,

There have been a lot of major changes to the General Hospital cast over the past few months!

The Daytime Emmy-winning soap opera series has been airing on ABC since 1963 and just celebrated its 62nd anniversary on April 1, 2025.

Over past several, there have been some big changes to the cast, including two stars leaving, a few returning, and several actors joining.

New episodes of General Hospital air weekdays on ABC and are available for streaming on Hulu.

Browse through the slideshow for all of the recent cast changes…