The cast of Grey’s Anatomy is sounding alarm bells about Season 22 — and it’s not just the usual medical mayhem. After the explosive finale of Season 21, several main characters are in jeopardy, and even the actors say nobody is safe.

Smoke, Ruins, and Survival: Who Made It Out?

By the end of Season 21, the hospital is in chaos after a bomb detonates. Only Meredith Grey (Ellen Pompeo) and Ben Warren (Jason George) are confirmed to have survived — “for now.” Showrunner Meg Marinis declined to confirm who else lived.

Still, the cast isn’t holding back about their fears. Camilla Luddington (Jo Wilson) admitted: “ We — Nobody knows. No one knows, which is terrifying. ” Meanwhile, Harry Shum Jr. (Blue Kwan) offered a dark (and hopeful) guess:

“Hopefully [it is] not me. Then

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