Sep 21, 2025; Philadelphia, Pennsylvania, USA; Philadelphia Eagles wide receiver AJ. Brown (11) reacts against the Los Angeles Rams during the second half at Lincoln Financial Field.

The 2025 NFL season has already reached Week 4 which means we've had one month of NFL action.

The USA TODAY Sports staff is back to deliver you the best NFL bets for Sunday. The team went 2-3 in Week 3, with Josh Jacobs finishing under his rushing yard prop and A.J. Brown finding paydirt at nearly 2-1 odds as the winners. Another week of information on player usage, defenses and injuries gives us data to make more informed decisions.

With a loaded 13-game slate for Sunday in NFL Week 4 that kicks off early with the first international game, the USA TODAY Sports staff of NFL experts narrows down the best NFL bets in one place below.

Our experts have provided the best prediction for this weekend's slate of games, selecting from any betting markets available and supplying an in-depth analysis on spreads, totals, player props and anytime touchdowns. Here are our best NFL bets for Sunday games with odds from BetMGM. Best of luck if you tail.

Best bets NFL Week 4

All odds listed are provided by BetMGM Sportsbook. Access USA TODAY Sports Scores and Sports Betting Odds hub for a complete list.

Eagles WR A.J. Brown OVER 63.5 receiving yards vs. Buccaneers (-118)

Ayrton Ostly, NFL writer: Since the 2022 NFL season, the Eagles are 1-2 against the Buccaneers in the regular season and playoffs combined. Tampa Bay has had its number better than most teams across the league - even more so when stretching back to the start of the Nick Sirianni and Jalen Hurts era (1-4 since 2021).

Coincidentally, the Eagles' lone win against the Buccaneers in that stretch - a 25-11 win in Week 3 of the 2023 season - is the only game that Brown suited up for Philadelphia. They obviously lost the two games to Tampa Bay before he arrived in 2022 but he was not in the lineup for the other two losses.

That lone win featured a nine-catch, 131-yard game by Brown with a game-high 14 targets in the passing game. Brown is healthy this week and could be the Eagles' key to getting past their pewter and red Boogeymen. Go for the over.

Tampa Bay Buccaneers (+3.5) vs. Philadelphia Eagles

Jacob Camenker, NFL writer: The Cowboys failing to score in the second half sunk our over bet last week but backing the Buccaneers ship seems like a good play in Week 4.

The Buccaneers have typically enjoyed success against the Eagles since Todd Bowles joined Tampa Bay's coaching staff in 2019. The Buccaneers are 4-1 straight up against the Eagles since then, including back-to-back wins by 17 points or more during the 2023 NFL playoffs and last season.

Some may be scared to back Tampa Bay given injuries to many of the team's starting offensive linemen and star wide receiver Mike Evans, but Baker Mayfield has proven he can do enough to keep the Buccaneers competitive. Expect them to cover in what should be a tightly contested game at Raymond James Stadium.

Patriots TE Hunter Henry OVER 37.5 receiving yards vs. Panthers (-118)

Nick Brinkerhoff, NFL writer: The Panthers ruined Week 3 in more ways than one, but we're targeting a matchup involving them in Week 4 anyway. After all, the only way out is through. Luckily for us, Henry comes into this game with a stellar matchup on tap.

The tight end already leads the Patriots with 22 targets this season and is tied for the most receptions with 13. That volume alone is enough to like our chances of getting at least 38 yards from Mr. Henry on Sunday afternoon, but a deeper dive has our confidence soaring to new heights.

Carolina plays zone defense 82.5% of the time – the fifth-highest rate in the league. Henry has been targeted 15 times against zone and hauled in 10 catches for 133 yards – which ranks second-most for tight ends against that coverage. As Drake Maye's de facto top weapon in the passing attack, Henry should be a busy man and cash our tickets with ease.

Bills WR Keon Coleman Anytime TD (+210)

Tom Viera, NFL writer/editor: The touchdown train is gaining steam entering Week 4 after nailing an anytime touchdown with A.J. Brown last Sunday. We're going to back second-year receiver Keon Coleman today when the Bills host the Saints. Coleman came storming out of the gates in Week 1 with eight receptions for 112 yards and a touchdown, but has been quiet since failing to surpass 30 yards.

The matchup with the Saints has us salivating at his opportunity for another massive output. New Orleans has played single-high at a top ten rate this season and Coleman led Buffalo with 2.49 yards per route run and ranked second in first read share (21.1%) against this coverage last season. Buffalo has the highest implied team total (31 points) of any team yet in 2025, so expect multiple scoring chances for the offense today. There's always a chance for a blowout and Buffalo dominating the day on the ground, so be sure to practice proper bankroll management.

This article originally appeared on USA TODAY: NFL best bets for Week 4 with expert predictions, player props for Sunday

Reporting by Tom Viera, USA TODAY / USA TODAY

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