Sep 18, 2025; Orchard Park, New York, USA; Buffalo Bills quarterback Josh Allen (17) runs against the Miami Dolphins in the second half at Highmark Stadium.

A pair of teams heading in opposite directions meet in Week 4, when the Buffalo Bills defend home turf against the New Orleans Saints.

The Saints have gotten some welcome returns from quarterback Spencer Rattler, who has thrown for four touchdowns to just one interception at this point in the season. Rattler is doing his best to hold off rookie quarterback Tyler Shough, whom the Saints selected in the second round of the 2025 NFL Draft.

Still, Rattler has played OK, but hasn't helped guide New Orleans and first-year head coach Kellen Moore to any wins just yet. If the losses keep coming, the Saints might go marching in a new direction at quarterback sooner rather than later.

Luckily for the Bills, quarterback is the last position they need to worry about. The Josh Allen-led offensive attack has gotten out to a fast, 3-0 start in 2025, picking up right where the 2025 NFL MVP left off.

While Buffalo had a commanding win over the New York Jets in Week 2, it took nearly the entire game clock to dispatch the Miami Dolphins in Week 3. A late Tua Tagovailoa interception sealed the deal for Buffalo, sending them to 3-0 on the season.

Will the Saints pull off a major upset, or will Buffalo roll to a 4-0 start on Sunday? Here's when you can catch the matchup.

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What time is the Bills vs. Saints game today?

  • Start time: 1 p.m. ET | 12 p.m. CT

The Bills-Saints Week 4 matchup kicks off at 1 p.m. ET from Highmark Stadium in Buffalo.

What TV channel is Bills vs. Saints today?

  • TV channel: CBS

The Bills and Saints will air at 1 p.m. on CBS. Andrew Catalon, Charles Davis and Jason McCourty will be on the call.

Bills vs. Saints live stream

  • Live stream: Fubo

For cord-cutters looking to stream the matchup, Fubo carries CBS, as well as ABC, NBC, Fox, NFL Network and the ESPN family of networks, meaning you'll be able to catch football action all season long with the streaming service.

Catch 2025 NFL action all season long with Fubo (free trial)

Bills vs. Saints injury report

2025 NFL schedule

This article originally appeared on USA TODAY: What time is Bills vs. Saints today? Kickoff time, TV channel for Week 4

Reporting by Joe Rivera, USA TODAY / USA TODAY

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