The Buffalo Bills will take on the New Orleans Saints in Week 4 of the NFL season at Highmark Stadium on Sunday, scheduled to start at 1 p.m. ET.

All week, questions about the status of Bills right tackle Spencer Brown and defensive end A.J. Epenesa have dominated headlines.

With both Brown and Epenesa remaining questionable for Week 4, linebacker Matt Milano has been ruled out , as has defensive tackle Ed Oliver.

Following these updates, Dimers analysts conducted 10,000 new simulations of the Bills vs. Saints matchup early Sunday morning. The results were compared to current odds to inform the data-driven Bills-Saints preview below.

Saints vs. Bills betting preview

This preview includes Dimers’ best bets and predicted scoreline for the New Orleans Saints vs. Buffalo Bills,

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