The New Orleans Saints face a tough fight when they try to stop the undefeated Buffalo Bills at home in Buffalo during NFL Week 4 on Sunday, September 28 (9/28/2025) at 1 p.m. ET.

Buffalo is one of just six remaining 3-0 teams in the league following their 31-21 win over AFC East rivals, the Miami Dolphins, last week. The New Orleans Saints, meanwhile, are 0-3, still on the hunt for their first win of the season. Josh Allen’s offense is leading the NFL in yards per game (420) and total yards (1,260), and Bills also lead the NFL in total rushing yards (489) and yards per game (163), with James Cook second in the league at 284 yards.

Saints vs. Bills will air on CBS, which you can stream on fuboTV (free trial) .

Here’s what you need to know:

What: NFL Week 4

Who: New Orlean

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