Two teams having very different seasons square off in NFL Week 4 as the Buffalo Bills (3-0) host the New Orleans Saints (0-3) on Paramount+ . Josh Allen and the Bills return to action after competing on Thursday Night Football in Week 3, topping the Miami Dolphins, 31-21. They will host a Saints side coming off of their biggest loss of the season, 44-13, to the Seattle Seahawks.

Kickoff from Highmark Stadium is set for 1 p.m. ET on CBS and Paramount+ . Buffalo is a 14.5-point favorite in the latest Saints vs. Bills odds from SportsLine consensus, while the over/under for total points scored is 48. The Bills are -1562 money line favorites (risk $1,562 to win $100), while the Saints are +868 underdogs. Before making any Bills vs. Saints picks, make sure you check out the picks from

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