SANTA CLARA — The post game press conference with 49ers coach Kyle Shanahan was nearing, with the last question dealing with the absence of Nick Bosa and the possibility of a trade.

Shanahan didn’t feel the need to expound on the obvious.

“You don’t replace Nick Bosa,” Shanahan said.

While a 26-21 loss to the Jacksonville Jaguars Sunday at Levi’s Stadium can’t entirely be laid at the feet (or right knee) of their best and highest paid defender, it was clear Bosa’s absence due to a torn ACL has changed the 49ers’ defense for the worse.

The 49ers never did sack Jacksonville quarterback Trevor Lawrence, whose jersey was kept clean while going 21-for-31 for 174 yards and a touchdown. Not that Lawrence gave the 49ers much of a chance, with a most of his throws of the high-percentage, get-th

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