Travis Etienne ran for 124 yards and a touchdown Sunday, Trevor Lawrence added a passing touchdown and the Jacksonville Jaguars handed the San Francisco 49ers their first loss with a 26-21 decision in Santa Clara, Calif.

Improving to 3-1 under first-year coach Liam Coen, Jacksonville secured the win with a big defensive play on a day they forced four turnovers. Arik Armstead sacked Brock Purdy, causing a fumble that teammate Foyesade Oluokun recovered at the San Francisco 47 with 2:47 left.

Lawrence, who completed 21 of 31 passes for 174 yards, hit Hunter Long for an 8-yard gain on 3rd-and-5 at the two-minute warning to help the Jaguars run out the clock.

Purdy finished 22-of-38 passing for 309 yards with two touchdowns and two interceptions. He threw 8- and 21-yard scoring strikes to C

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