Traders work on the floor at the New York Stock Exchange (NYSE) in New York City, U.S., September 17, 2025. REUTERS/Brendan McDermid

By Niket Nishant and Sukriti Gupta

(Reuters) -U.S. stock index futures rose on Monday, in a firm start to a potentially eventful week, as investors await remarks from a slate of Federal Reserve policymakers and weigh the threat of a government shutdown.

The in-line inflation print on Friday helped keep rate cut bets alive, helping the three major indexes to notch up gains even as they posted losses for the week.

At 06:47 a.m. ET, Dow E-minis were up 202 points, or 0.43%, S&P 500 E-minis were up 36.75 points, or 0.55%, and Nasdaq 100 E-minis were up 162.5 points, or 0.66%.

Attention is now riveted on a standoff between Republicans and Democrats over funding that has raised the prospect of a shutdown beginning Wednesday, the first day of the U.S. government's 2026 fiscal year.

"If there is a shutdown, and the Bureau of Labor Statistics cannot publish the employment or inflation data, an October cut is at risk of being delayed," Thomas Simons, chief U.S. economist at Jefferies, said.

President Donald Trump's administration has also threatened to permanently remove workers from some federal agencies if funding runs out, a move that could lead to a spike in jobless claims for October.

"We are in uncharted territory here, to some extent, so it is too early to tell what the eventual impact might be," Simons said.

The developments come at a critical juncture for markets, as any disruption to economic data could muddy the outlook and inject fresh volatility.

Fed officials have stressed their data-dependent approach and losing visibility into key indicators could complicate policy decisions.

Cleveland Fed President Beth Hammack, in an interview with CNBC on Monday, said the central bank needs to maintain restrictive monetary policy to keep inflation in check.

Several other Fed policymakers are also scheduled to speak through the day, including New York Fed President John Williams, St. Louis Fed President Alberto Musalem, Atlanta Fed President Raphael Bostic and Fed Governor Christopher Waller.

Investors will be watching closely for any signs of concern over the potential loss of economic visibility should a shutdown materialize.

Also on the docket on Monday is the National Association of Realtors' pending home sales index for August. A leading indicator of housing activity, the report comes as the sector continues to struggle with elevated mortgage rates.

In premarket trading, U.S.-listed shares of cannabis-related companies rose, with Canopy Growth and Cronos Group climbing 19.4% and 9.5%, respectively, while Tilray Brands added 20.9%. Trump on Sunday shared a video promoting the health benefits of hemp-derived cannabidiol.

U.S.-listed shares of Merus NV surged 37.7%, after Danish pharmaceutical company Genmab agreed to acquire the Dutch biotech firm for $8 billion in cash.

MoonLake Immunotherapeutics slumped 87.3%, after the company released late-stage study data for a skin disease drug.

(Reporting by Niket Nishant and Sukriti Gupta in Bengaluru; Editing by Sriraj Kalluvila and Shilpi Majumdar)