The Week 6 college football odds board is loaded with high-profile matchups that could have potential College Football Playoff implications. Among the notable Week 6 college football betting lines is No. 10 Alabama (-10.5, 55.5) vs. No. 16 Vanderbilt, No. 18 Florida State vs. No. 3 Miami (-4.5, 54.5), No. 9 Texas (-6.5, 43.5) vs. Florida, Boise State vs. No. 21 Notre Dame (-18.5, 64.5), and No. 11 Texas Tech (-10.5, 50.5) vs. Houston. The biggest Week 6 college football spread sees the Oklahoma Sooners as 45.5-point favorites at home over the Kent State Golden Flashes.

How should you make college football picks for those games, and what are the best spread, total and money-line picks to include in college football best bets? Before locking in any Week 6 college football picks, be sure to

See Full Page