All lanes of eastbound Interstate 4 have reopened after the highway was shut down near mile marker 72 on Monday afternoon due to multiple crashes in the area.
Five people were transported to area hospitals from the crashes, Florida Highway Patrol said.
One of the vehicles involved was a semi that overturned.
Eastbound traffic had been detoured onto International Drive before getting back on I-4 eastbound from Sand Lake Road.
>> This is a developing story and will be updated