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NFL picks, predictions against the spread Week 5: Chiefs cool Jaguars, Cowboys best Jets

The first four weeks of the 2025 season are really a feeling-out period to figure out the true identities of all 32 teams. Some teams are easier to read than others and what types of performances to expect from week to week, depending on location, talent and quality of opponent. Others remain inconsistent enigmas.

Trends can become a bigger factor in the picks and predictions against the spread. Week 5 brings a little break with four teams on bye and two fewer games than a full slate. That makes less that can go wrong, but also two fewer chance

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